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to characterize the epignetic landscapre of MPN and sAML, uncover the molecular mechanisms underlying disease progression and treatment resistance and identify novel therapeutic targets. You will take a lead on
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of selective bioactive molecules targeting transporter proteins, and the design and synthesis of bifunctional molecules for bioorthogonal chemistry, including the synthesis of diazirines, will also be pursued
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-specific molecular pathways can be identified that are suitable as potential drug targets in ARHL. The post-holder will work in the lab of Dr Lisa Nolan to support the development of a single-cell RNA-Seq
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culture and organoids to ensure data is clinically relevant. Our overarching aim is to utilise these techniques to identify therapeutic targets to which we can generate effective treatments. The post would
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potential drug targets in ARHL. The post-holder will work in the lab of Dr Lisa Nolan to support the development of a single-cell RNA-Seq pipeline for cochlear tissue that is suitable to translate to our
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pathway, ribosomal translational control and mitochondrial function, and their regulation by PIM kin ases, to further our understanding of PIM kinases in T cells for therapeutic targeting in autoimmune
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renewable award. You will lead a programme of research in the molecular mechanisms of cardiovascular disease, that may include a range of approaches including targeted genetic murine models, primary cell
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facilely applied as a photoluminescent layer, targeting in situ detection and non-contact visualization of surface temperatures and pressures. You should hold a PhD/DPhil (or near completion*) in materials
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targeted training, and engage with MSc and PhD students. What we are looking for: You will have a strong educational profile up to and including a PhD Degree or equivalent in a relevant discipline (applied
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targets. You will take a lead on development of computational approaches to integrate multi-omics data from patient samples, including DNA methylation, histone modifications, single-cell transcriptomics and