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help develop and characterise advanced patient-derived tumour models and use them to test promising therapeutic targets that exploit vulnerabilities caused by loss of the SMARCB1 gene. This role offers
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to the skin, hair and nail, the use of skin stretching to promote needleless delivery, the use of nanomaterials in the oral and respiratory mucosa, targeting hair follicles using nanosystems and the use of 3D
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primary headache disorders and related co-morbid conditions to help uncover novel disease mechanisms that can lead to the development of novel therapeutic targets. The individual will report to the PI
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into disease progression, with the ultimate aim of identifying novel biomarkers and therapeutic targets. You will hold a relevant PhD/DPhil, together with sufficient specialist knowledge in normal and malignant
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targets. You will hold a relevant PhD/DPhil, together with sufficient specialist knowledge in normal and malignant hematopoiesis research. Experience generating genomics data from leukaemia samples with
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in preventing immune-mediated pathology in autoimmunity remains poorly understood. Using genetic and antibody-based targeting, we aim to dissect how these pathways modulate T-cell signalling
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dedicated high-performance computing implementations. Technology transfer to magnetic resonance imaging in medicine is a secondary target. Key Duties and Responsibilities The postholder will develop new image
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characterising binding interactions. You will drive the completion of several mature projects to publication, including revealing new roles for disordered domains in efficient DNA target search. You may also
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and electrophysiology approaches. Age-related metabolites will be targeted to improve the efficiency of generating functional hiPSC-CMs to improve therapeutic options for aged patients. The results
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therapeutic targets. The individual will report to the PI of the headache Group, Dr Philip R Holland and will be responsible for conducting their own independent research projects, the supervision of more