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will be grounded in rigorous mathematics coupled with a sound understanding of the underlying earthworm ecology. Bayesian inference methodologies will be developed to estimate where and when behavioural
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to understand of how these mutations disrupt healthy brain development, how brain changes relate to patient symptoms and how to best target treatment. This project seeks develop tools to better understand
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The construction industry accounts for 8–10% of global anthropogenic CO₂ emissions and faces significant challenges in achieving NetZero targets by 2050. This PhD project offers an exciting
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that target diverse biological processes. These include DNA replication, transcription, translation and cell signaling. To exemplify, nucleoside analogues possess an accomplished history within therapeutic
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brain development, how brain changes relate to patient symptoms and how to best target treatment. This project seeks develop tools to better understand, diagnose, monitor and target in children with
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planned acts, such as targeted terrorist activities. This exciting project will focus on developing a mathematical model (and a supporting research software) to predict the key performance indicators of a
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), patent applications and commercialisation (e.g. UoE spinout, MitoRx Therapeutics ). Here, you will design, synthesise and characterise novel potential drug structures to target intracellular structures
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Agrobacterium-mediated transient expression in Nicotiana benthamiana. This will test whether minibinders are able to disrupt and ameliorate the known phenotypes of their target effector. We anticipate
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the student with training in diverse techniques related to molecular and cellular biology, bioinformatics and protein biochemistry. A key activity in this project will be the use of targeted reverse genetics
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’, adopting distinct structural forms each tailored to functionally specific downstream targets. Initial cryo-electron microscopy (cEM) studies show that MRFAP1 forms a remarkable dodecameric ‘nanocage’ which