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://doi.org/10.1172/jci99169 ). However, a host of interconnected metabolic and immune pathways likely regulate tumour progression. Identification of these novel mechanisms will provide new targeted therapeutic
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, alongside complex drug screening, efficacy and clinical phenotype information. Using these datasets, you will undertake comprehensive strategies aimed at the characterisation and therapeutic targeting
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limited. No immunotherapy for meningiomas has yet gained FDA approval, though early-phase trials targeting IFN-alpha and PD-1 have been conducted. Emerging evidence highlights the crucial role of the immune
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of the project is the optimisation of compounds that inhibit a critical protein target that will lead to drugs for currently untreated cancer types. It employs cutting-edge structure based drug design and property
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of Health and Life Sciences. Prostate cancer is highly heritable and a good target for genetic risk stratification. Prostate cancer genetic risk scores (GRS) aggregate common variants into a predictive score
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. The current PhD projects will partner with researchers in other countries including Mexico and/or Zimbabwe, to run targeted research studies which expand upon the large trials in new cultural contexts (2
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molecular switches that could be targeted by anti-fibrotic drugs. You will master • genome editing, • human iPSC culture and directed differentiation, • live cell biomechanical imaging, and • multiomics
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Targeting Cardiometabolic Dysfunction in Heart Failure with Preserved Ejection Fraction (HFpEF): Mechanisms of Exercise-Induced Protection Overview Applications are invited for a fully funded 4-year
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treatments that target AR have forced cancer cells to evade treatment and a newly characterised, but frequent escape mechanism is for cancer cells to lose dependence on AR and to take on features of a
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target, since all known treatment resistance mechanisms are downstream of, and dependent on FOXA1. However, FOXA1 has been a difficult protein to study for technical reasons. We have developed a novel tool