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experiments. The objective is to develop Bayesian causal models and neural networks capable of identifying relevant causal relationships between instrumental parameters and observed anomalies. The work will
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computational models to map and analyze interactions within biological networks, thereby identifying key pathways and targets for therapeutic intervention. -Simulations and Virtual Drug Screenings: Aiding in drug
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Background: The nuclear oncology team has a long-lasting expertise in the development of targeted alpha therapy and is internationally recognized for its research on astatine-211 labeling chemistry
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malignancies. Leukemia. 2023;37(4):864-876. Kumar S, Schoonderwoerd MJA, Kroonen JS, et al. Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell
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Programmed Cell Death-1 (PD-1). PD-1 targeted therapies elicit clinical responses in different cancertypes, but response rates are rarely above 20%. Positive outcomes have been associated with CD8T cell
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Postdoctoral position: Developing a human lymphoid organ-on-chip to evaluate candidate mRNA vaccines
on the LO chip, to better evaluate the potential of candidate mRNA vaccines to target mucosal pathogens. Further developments will aim at evaluating the predictive power of the LO chip assay and at increasing
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areas—targeted at master's or engineering students, but also professional and expert-level audiences. Research activities will be carried out in one of the research laboratories affiliated with the 3IA
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target regions of interest (e.g interface between parasite and host cell organelles) for FIB milling and cryoET data collection. Phase contrast tomography of these samples is already providing
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to target the mechanistic alterations at the basis of resistance to current therapeutic options. The research program will favor translational approach and the experimental design will benefit from
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the boundaries of cellular reprogramming by introducing scalable computational methods that streamline the discovery of reprogramming targets and control strategies. A key innovation of EdgeCR is its