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analysis and machine learning methods applied to protein structure determination using single-particle cryo-electron tomography (ET). The candidate will contribute to the design, development, and
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clinical trials in patients with cancer; to identify and validate predictive biomarkers of clinical outcomes in cancer; and perform meta- analyses using the Bayesian framework. The projects will lead to both
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patients with cancer; to identify and validate predictive biomarkers of clinical outcomes in cancer; and perform meta- analyses using the Bayesian framework. The projects will lead to both collaborative and
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methods like umbrella sampling, force integration, free energy perturbation, or lambda integration to compute the conformational behavior of individual structures and the thermodynamic stability of assembly
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. The Department of Biochemistry provides a rich intellectual environment, with research in structural biology (cryo-EM, X-ray crystallography, NMR spectroscopy), and computational biology. Duke’s benefits package
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be translated into biologics and vaccines. DHVI is composed of a team of highly interactive investigators that have expertise in mucosal and systemic immunology, virology, molecular and structural
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groups that are historically underrepresented in physics departments. These researchers will work with Prof. Michael Troxel to lead large-scale structure (weak lensing and galaxy clustering) projects