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plasticity at the atomic level. At the center of this regulation lies PGC-1α, a transcriptional co-activator and master regulator of metabolic processes. PGC-1α dysfunction has been linked to obesity, diabetes
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. A human metabolic map of pharmacological perturbations reveals drug modes of action. Nature Biotechnology (2025) Ortmayr, K., de la Cruz Moreno, R. & Zampieri, M. Expanding the search for small
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demonstrating how an existing anti-biofilm compound binds to and activates its specific target in Pseudomonas aeruginosa, we will design, develop and test novel anti-biofilm compounds with broader activity
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the lab, and at the same time to play an active role in shaping and creating an inspiring research and working environment. In line with our and Uni Basel values (https://www.unibas.ch/en/Research/Values
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cancer; see https://data.snf.ch/grants/grant/189065 Design, development and implementation of multi-step synthesis to access small heterocyclic molecules. Improve biological activity of hit compounds
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constructively with colleagues in ways that support the project's progress Teaching responsibilities of no more than 20%, including: grading short-essay assignments preparing multiple-choice questions
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Teaching responsibilities of no more than 20%, including: grading short-essay assignments preparing multiple-choice questions for an introductory course, partly depending on your background in marketing
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activates its specific target in Pseudomonas aeruginosa, we will design, develop and test novel anti-biofilm compounds with broader activity against the WHO priority pathogens Escherichia coli, Klebsiella
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their own research questions. They are expected to collaborate closely with other team members and researchers from other institutions, will co-supervise PhD and MSc students, and contribute to teaching and