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contexts This project aims to fill this gap in knowledge by combining quantitative mass spectrometry-based proteomics, CRISPR/Cas genome targeting and targeted next generation sequencing technologies
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associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins that regulate R-loops in human cells and discovered a role
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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
internal reflection microscopy)-based platforms. Later, the in vitro findings will be supported and validated by cell biology-based assays. The establishment of BIR at single-molecule level will be
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chemosensory genes in nearly all species. Based on the canonical model of the olfactory circuit, a single OR is expressed in each Olfactory Receptor Neuron (ORN), which projects to a single OR-specific
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from diseases such as cancer, premature ageing, inflammation and neurodegeneration. In our lab, we have developed a proteomics-based method, named “LinkageID”, to systematically isolate cellular factors
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APCs in the CNS that are involved in the interaction with CD4+ T cells. It is based on the interaction between CD40, expressed by APCs, and CD40-ligand, expressed by T cells. When two cells interact with
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described by us in past work. However, studies on piRNA precursors have been hampered by a number of technical aspects. In the past years, we have developed a reporter system, based on GFP silencing
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shown to function in the regulation of gene expression. A previous study generating a genome-wide R-loop atlas for the model plant Arabidopsis thaliana using ssDRIP-seq (single-strand DNA ligation-based