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or altered behavioral responses in ASD models How these changes reflect underlying shifts in cortical circuit function You will work within the Bonin and Farrow Labs, which brings deep expertise in
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are based at Campus Gasthuisberg in Leuven, Belgium, and our research explores how inhibitory brain circuits are wired during development. We use a wide array of techniques including mouse genetics, advanced
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diverse classes of inhibitory neurons are specified and integrated into brain circuits during development. Our work bridges developmental neurobiology, disease modeling, and systems neuroscience. To do
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, (3) the development of translational strategies in circuit neuroscience and (4) the development of computational models and methods for neuroscience. The goal is to implement AI-based methods and
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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regulation using single-cell and spatial multi-omics data; AI-based modeling of protein structure and protein interaction networks; AI-based modeling of cell morphology and tissue function using imaging and
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central goal is to understand how these effects are shaped by human-specific SRGAP2 genes, which regulate synaptic timing via SYNGAP1. To achieve this, we will use: Xenotransplantation models of human
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translational cancer research. Omics based strategies, such as (epi-)genomics and transcriptomics, are opening unprecedented potential for developing novel precision oncology tools for improved diagnosis
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training data. You will unravel the cis-regulatory code controlling context-dependent gene expression and use this information to design synthetic promoters. You will train and evaluate predictive models in