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chemosensory genes in nearly all species. Based on the canonical model of the olfactory circuit, a single OR is expressed in each Olfactory Receptor Neuron (ORN), which projects to a single OR-specific
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shown to function in the regulation of gene expression. A previous study generating a genome-wide R-loop atlas for the model plant Arabidopsis thaliana using ssDRIP-seq (single-strand DNA ligation-based
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experimental autoimmune encephalomyelitis (EAE), a mouse model for the human autoimmune disease of the central nervous system (CNS) multiple sclerosis (MS). In EAE, dendritic cells (DCs) play an important role
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to trained immunity in models of infection and inflammation. Dendritic cells play a fundamental role in antigen presentation and the priming of naive T cells. They are short lived and constantly replenished by
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of the hematopoietic system. Proteases of the coagulation system have been implicated in the regulation of the fate of HSC (extravascular coagulation signaling) in homeostatic condition as well as in aging mouse models
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pipelines for pre-processing, normalization, and statistical modeling of high-throughput sequencing data. Integrate and mine public datasets to complement in-house generated data and extract novel biological
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metabolic pathways involved in T-cell aging using advanced genetic models that allow for parallel CRISPR perturbation of multiple metabolic genes at the single-cell level. Determining the impact of metabolic
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degradation. This will allow us to model developmental diseases and unravel the physiological role of BAF subunits and specific BAF complexes in human developmental processes. With the help of bulk and single
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to DNA damage sites, using a combination of in vitro and cellular model systems. Specifically, we aim to address the following questions: 1) Does TDP-43 help to resolve R-loops by directly binding to RNA
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contexts This project aims to fill this gap in knowledge by combining quantitative mass spectrometry-based proteomics, CRISPR/Cas genome targeting and targeted next generation sequencing technologies