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functions, lead to substantial T and B cell infiltrates, reminiscent of tertiary-lymphoid structures (TLSs) (Allen E. et al Sci Transl Med 2017, Hua et al. Cancer Cell 2022; Guelfi et al. Nat Rev Cancer 2024
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are seeking a motivated and enthusiastic colleague with strong computational skills in the analyses of complex data sets to join our teams. About the project We have generated advanced brain on chip models
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, or related discipline. Expertise in macrophage biology and strong interest in neurodegenerative disorders, in particular Parkinson’s disease. Proven experience with transgenic mouse models and techniques like
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temperature signalling in plants, such as the model plant Arabidopsis thaliana and the crop plants wheat and soybean. To unravel this, we focus on dynamic changes in protein phosphorylation status, since
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project that combines cutting-edge approaches including state-of-the-art imaging techniques, pluripotent stem cell models, in vivo mouse models of neurological disorders, drug (brain) delivery and nanobody
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researcher to study the complexity and heterogeneity of both mouse and human microglia in neurodevelopment and neurodegeneration. By using state of the art spectral flow cytometry you will develop advanced
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this specificity and test how these regulate structure and function of higher-order thalamocortical inputs in cortical circuits. The applicant will use various technologies, including super-resolution imaging
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question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse
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metastasis and novel metabolic pathways. We exploit mouse models, genetic engineering, metabolomics and single cell & spatial multi-omics analysis to gain groundbreaking insights into metabolism as a driving
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the results into new economic growth. Within VIB, the VIB-VUB Center for Structural Biology is located on the Brussels campus of the Vrije Universiteit Brussel and hosts 10 PIs with varying expertise but all