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question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse
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metastasis and novel metabolic pathways. We exploit mouse models, genetic engineering, metabolomics and single cell & spatial multi-omics analysis to gain groundbreaking insights into metabolism as a driving
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identity and establish proper connectivity with brain targets during development. To this end, Esther and her team use advanced technologies like single-cell and spatial transcriptomics and connectomics
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actively seeking a postdoctoral bio-informatician to advance the liquid biopsy research in the team. An important aim in TOBI is the development of novel assays for diagnosis and monitoring cancer patients
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metabolites using metabolomics and synthetic biology. This will involve advanced technologies such as (un)targeted metabolite profiling, bioactivity assays, and CRISPR/Cas-based gene editing in fungi